Testosterone is a potent inhibitor of L-type Ca(2 ) channels.

Testosterone is a potent inhibitor of L-type Ca2+ channels

The major finding of this study is that testosterone is a selective and potent inhibitor of L-type Ca 2+ channels, effective within the physiological range. This observation can account for its long-known beneficial vasodilatory effects , , . Channel inhibition was rapid even when recording currents at room temperature, and during intracellular dialysis with patch pipettes, making it unlikely to be mediated …

Testosterone is a potent inhibitor of L-type Ca channels

Testosterone is a potent inhibitor of L-type Ca channels Article in Biochemical and Biophysical Research Communications 318(2):503-6 · June 2004 with 14 Reads DOI: 10.1016/j.bbrc.2004.04.054

Testosterone is a potent inhibitor of L-type Ca 2+ channels

Read «Testosterone is a potent inhibitor of L-type Ca 2+ channels, Biochemical and Biophysical Research Communications» on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

Published in: Biochemical and Biophysical Research Communications · 2004Authors: Jason L Scragg · Richard D Jones · Kevin S Channer · T Hugh Jones · Chris PeersAffiliation: University of Leeds · University of Sheffield · Royal Hallamshire HospitalAbout: Vascular smooth muscle · Coronary artery disease · Testosterone

Testosterone and the Cardiovascular System: A

This suggests that testosterone inhibits the L‐type Ca 2+ channel. An inhibition of T‐type Ca 2+ channels was also seen, but only at supraphysiological testosterone levels. 23 Thus, testosterone may have further vasodilatory effects at supraphysiological levels.

Selective Inhibition of L-Type Ca 2+ Channels in A7r5

We demonstrate that testosterone directly inhibited both native and human recombinant vascular L-type Ca(2+) channels in a manner that was voltage-independent and, crucially, displayed an IC(50

Testosterone-induced relaxation of coronary arteries

Scragg JL, Jones RD, Channer KS, Jones TH, Peers C. Testosterone is a potent inhibitor of L-type Ca 2+ channels. Biochem Biophys Res Commun 318 : 503–506, 2004 [ PubMed ] 34.

Selective Inhibition of L-Type Ca 2+ Channels in A7r5

We have shown recently that testosterone is a potent inhibitor of recombinant L-type calcium channels in HEK 293 cells stably transfected with the α 1C subunit of the human cardiovascular L-type calcium channel (Ca v 1.2), using patch-clamp electrophysiological recordings.

Mechanisms involved in testosterone-induced vasodilatation

Testosterone vasodilatation is suggested to be produced via blockade of extracellular Ca 2+ entry through L-type VOCCs and non-L-type Ca 2+ channels.

Testosterone and Cholesterol Vasodilation of Rat Aorta

Advances in Pharmacological Sciences is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all …

Testosterone and the Cardiovascular System: A

23 Scragg JL, Jones RD, Channer KS, Jones TH, Peers C. Testosterone is a potent inhibitor of L‐type Ca(2+) channels. Biochem Biophys Res Commun . 2004 ;318:503–506.

Dr. Richard Jones, Pediatrician in Fresno, CA | US News

Dr. Richard Jones is a pediatrician in Fresno, California and is affiliated with multiple hospitals in the area, including Fresno Surgical Hospital and St. Agnes Medical Center.

Regulation of the sperm calcium channel CatSper by

The calcium channel of sperm—CatSper—is vital for male fertility. CatSper is activated by the hormone progesterone, but its pharmacological profile is not well studied. By exploring steroid selectivity of CatSper activation, we found one additional agonist—pregnenolone sulfate—and the two plant-derived inhibitors pristimerin and lupeol.

Pharmacological evidence that Ca 2+ channels and, to a

Read «Pharmacological evidence that Ca 2+ channels and, to a lesser extent, K + channels mediate the relaxation of testosterone in the canine basilar artery, Steroids» on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

Published in: Steroids · 2011Authors: Martha B Ramirezrosas · Luis E Cobospuc · Enriqueta Munozislas · Abimael Gonzalez…Affiliation: Cinvestav · Erasmus University RotterdamAbout: Iberiotoxin · Calcium channel · Voltage-gated potassium channel · Fissipedia · Cyclo…

Testosterone Relaxes Rabbit Seminal Vesicle by Calcium

Scragg JL, Jones RD, Channer KS, Jones TH, Peers C. Testosterone is a potent inhibitor of L-type Ca $^{2+}$ channels. Biochem Biophys Res Commun 318: 503-506, 2004 Biochem Biophys Res Commun 318: 503-506, 2004

Published in: The Korean Journal of Physiology and Pharmacology · 2008Authors: Jong Kok Kim · Woo Ha Han · Moo Yeol Lee · Soon Chul Myung · Sae Chul Kim · Min …Affiliation: Chung Ang UniversityAbout: Calcium channel · Seminal vesicle · Ejaculation · Testosterone · Bioinformatics